LIG3 anticorps

N° du produit ABIN3022649

Cet anticorps Lapin Polyclonal détecte spécifiquement LIG3 dans WB et IHC. Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 2+ publications.

Aperçu rapide pour LIG3 anticorps (ABIN3022649)

Antigène: LIG3 (Ligase III, DNA, ATP-Dependent (LIG3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LIG3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-LIG3 anticorps

Purification: Affinity purification

Immunogène: Recombinant protein of human LIG3

Isotype: IgG

Information d'application

Indications d'application: Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C/-80 °C

Références pour anticorps anti-LIG3 (ABIN3022649)

Li, Zhang, Chen, Guo, Zhang, Tang, Xu, Zhang, Tao, Wang, Jiang, Sun, Mao: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." dans: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).

Xu, Zhang, Zhang, Meng, Zhang, Jiang, Xu, Van Meter, Seluanov, Gorbunova, Mao: "SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner." dans: Cell cycle (Georgetown, Tex.), Vol. 14, Issue 2, pp. 269-76, (2015) (PubMed).

Détails sur LIG3

Antigène: LIG3 (Ligase III, DNA, ATP-Dependent (LIG3))

Autre désignation: LIG3

Sujet: This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Synonyms: LIG2, LIG3

ID gène: 3980

UniProt: P49916

Pathways: Réparation de l'ADN